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Compared with naproxen, celecoxib at doses of 3 and 6 mg/kg BID had no observable deleterious effect on growth and development during the course of the 12week doubleblind study.
Warnings signs for liver damage include nausea, vomiting, tiredness, loss of appetite, itching, yellow skin or eyes, dark urine, flulike symptoms.
All orders are filled and shipped in accordance with the local rules, regulations, and laws applicable to the pharmacy that is filling and shipping the order.
If you notice any of these symptoms you should stop taking this drug immediately and check with your physician.
Patients should be informed of the signs and symptoms of ulcerations and bleeding, and to seek immediate medical advice if they observe any signs or symptoms that are indicative of these disorders, including epigastric pain, dyspepsia, melena, and hematemesis.
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Longterm administration of NSAIDs has resulted in renal papillary necrosis and other renal injury.
This means a drug might give its intended response in a certain dose, but if that does is exceeded, the drug might become toxic and lead to permanent harm.
Data sources include Micromedex updated Oct 20th, 2011, Cerner Multum updated Oct 19th, 2011, Wolters Kluwer updated Nov 4th, 2011 and others.
Celecoxib blocks the enzyme that produces Prostaglandins a chemical that contributes to inflammation of arthritis in turn resulting in pain, fever, swelling and tenderness.
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